Diabetes Genetics Initiative

Results Summary

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Sample inclusion and exclusion criteria:

Cases: Cases were selected according to ADA (2003) definitions of type 2 diabetes (fasting plasma glucose > 7.0 mM or 2 hour postload glucose during an OGTT >11.1 mM). To avoid confounding with type 1 diabetes, GAD Ab positive patients were excluded. To exclude MODY diabetes, subjects from families with mutations in known MODY diabetes genes and diabetic individuals with onset age < 35 years were excluded.

Results Summary

The interpretation of genome-wide association results can be greatly facilitated by visualization.

Summary

PDF

Sample inclusion and exclusion criteria:

Cases: Cases were selected according to ADA (2003) definitions of type 2 diabetes (fasting plasma glucose > 7.0 mM or 2 hour postload glucose during an OGTT >11.1 mM). To avoid confounding with type 1 diabetes, GAD Ab positive patients were excluded. To exclude MODY diabetes, subjects from families with mutations in known MODY diabetes genes and diabetic individuals with onset age < 35 years were excluded.

ⁱ Fan JB, Oliphant A, Shen R, Kermani BG, Garcia F, Gunderson KL, Hansen M, Steemers F, Butler SL, Deloukas P, Galver L, Hunt S, McBride C, Bibikova M, Rubano T, Chen J, Wickham E, Doucet D, Chang W, Campbell D, Zhang B, Kruglyak S, Bentley D, Haas J, Rigault P, Zhou L, Stuelpnagel J, Chee MS (2003) Highly parallel SNP genotyping. Cold Spring Harb Symp Quant Biol. 68, 69-78.

Characteristics of cases and controls

We do not find significant evidence for association anywhere in the genome:

Project leaders

David Reich, Broad Institute, Harvard (principal investigator)
Jim Wilson, Jackson Heart Study (principal investigator)
Herman Taylor, Jackson Heart Study
Brian Henderson, Multi-Ethnic Cohort
Laurence Kolonel, Multi-Ethnic Cohort

Project Members

Gavin McDonald, Broad Institute
Meggie (Ermekgul) Akylbekova. Jackson Heart Study