Chemical Biology

Molecular Libraries Probe Production Center Network (MLPCN). The Broad Institute’s Comprehensive Screening Center was established in 2008 in order to discover and develop small-molecule probes and is sponsored by the NIH Road Map's Molecular Library Initiative. The Center engages in ~25 small-molecule probe development projects each year, which entails assay development, HTS, and follow-up chemistry and biology. All facets of the research are made available on the public databases PubChem and ChemBank.

The Broad Institute CMLD (Centers of Excellence in Chemical Methodology and Library Development) is a National Institute of General Medical Sciences (NIGMS)-funded center dedicated to innovation in the area of synthetic organic chemistry. Chief among the goals of the CMLD is the development of new synthetic methods that can expand the chemical diversity of small-molecule libraries.

The Chemical Biology Program has dedicated a significant effort toward understanding pancreatic beta-cell function and proliferation in the context of type-1 diabetes, a disease resulting from the autoimmune destruction of these beta cells. Even the most rigorous attempts to manage blood glucose fall short of the exquisite regulation achieved by unimpaired pancreatic islets. Consequently, a therapeutic approach that restores islet function in vivo with the use of small molecules would offer exceptional benefit to diabetic patients.

• Chemical Biology Program
  • Overview
  • Team
• Chemical Biology Platform
  • Overview
  • Team
• Related Projects
  • ICG Project Team
    
  • MLPCN Project Team
    
  • JDRF Project Team
  • CMLD Project Team
    

The following publications have benefited, directly or indirectly, from the National Cancer Institute’s Initiative for Chemical Genetics. Direct benefits include screening, assay development, synthetic chemistry, analytical chemistry and computational support at the ICG. Indirect benefits include the mining of assay or chemical data that were originally developed at the ICG.

Program Leadership

Stuart Schreiber, Director
Alykhan Shamji, Associate Director
Christine Malinowski, Program Manager
Paul Clemons, Director of Computational Chemical Biology Research
Bridget Wagner, Group Leader in Pancreatic Cell Biology and Metabolic Disease
Angela Koehler, Project Leader, Small-Molecule Microarrays
Damian Young, Project Leader, CMLD