Broad Institute of MIT and Harvard

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2008

A mitochondrial protein compendium elucidates complex I disease biology, Pagliarini, D.J.; Calvo, S.E.; Chang, B.; Sheth, S.A.; Vafai, S.B.; Ong, S.; Walford, G.A.; Sugiana, C.; Boneh, A.; Chen, W.K.; Hill, D.E.; Vidal, M.; Evans, J.G.; Thorburn, D.R.; Carr, S.A.; Mootha, V.K. , Cell, 2008/07/11/, Volume 134, Issue 1, p.112 - 23, (2008) Abstract
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Supplemental Materials
Files Paper Figures Supplement Classics Res File Classics Class File NonClassics Res File NonClassics Class File CEL Files Files Manuscript (PDF) Supplementary Information document (MS Word) Figures (MS Power Point) Datasets and clinical table (ZIP, 13 Mbytes) Sample list Raw data 1/4 (57 MB) Raw data 2/4 (57 MB) (57 MB) Raw data 3/4 (58 MB) (57 MB) Raw data 4/4 (58 MB) Dataset C (gene expression) RES file format Dataset C (class labels) CLS file format Dataset C (clinical table) ASCII file format Files Supplementary Appendix 1 Supplementary Figure A4-1 Supplementary Figure A6-1 Supplementary Figure A6-2 Supplementary Figure A2-1 Supplementary Table 1 Supplementary Table 2 Supplementary Table 3a Supplementary Table 3b Files Supplementary Information URLs Medical News Today URLs Blood Highlight Files Manuscript Figures References Raw data (mean scaled, see supplement) Raw data (unscaled) Sample annotation 2118 genes (Top 5% by F statistic) 4246 genes (Top 10% by F statistic) ASH meeting presentation (slides) ASH meeting presentation (handouts) UNIGENE and GenBank annotation of Affymetrix UNIGENE and GenBank annotation of Lymphochip Lymphochip 2 Affymetrix mapping Consensus Clusters' Markers URLs PNAS Supplemental Information Files PGC-1-alpha timecourse (scaled expression data) Mouse promoters Mouse:human masked promoters Gene list for Figure 1 correlogram Files Technical Report Leukemia data Leukemia class template Novartis multi-tissue data Novartis multi-tissue class template St. Jude Leukemia data St. Jude Leukemia class template Lung cancer data Lung cancer class template CNS tumors data CNS tumors class template Normal tissues data Normal tissues class template Uniform1 Gaussian1 Gaussian3 Gaussian3 class template Gaussian4 Gaussian4 class template Gaussian5.delta2 Gaussian5.delta3 Gaussian5 class template Simulated6 Simulated6 class template URLs Same datasets as this paper Files Paper (Word document) URLs Multi-tumor Cancer Map Paper Lung Paper Breast Paper Prostate Paper Medulloblastoma Paper Lymphoma Paper Files Manuscript Supplement Supplemental Information Dataset A - Global Cancer Map Tumor vs. Met. Dataset B - Lung Outcome Dataset C - Rosetta Breast Outcome Dataset D - Prostate Outcome Dataset E - Medulloblastoma Outcome Dataset F - LBC Lymphoma Outcome Table of Contents

Supplemental Materials

Files
Paper
Figures
Supplement
Classics Res File
Classics Class File
NonClassics Res File
NonClassics Class File
CEL Files
Files
Manuscript (PDF)
Supplementary Information document (MS Word)
Figures (MS Power Point)
Datasets and clinical table (ZIP, 13 Mbytes)
Sample list
Raw data 1/4 (57 MB)
Raw data 2/4 (57 MB) (57 MB)
Raw data 3/4 (58 MB) (57 MB)
Raw data 4/4 (58 MB)
Dataset C (gene expression) RES file format
Dataset C (class labels) CLS file format
Dataset C (clinical table) ASCII file format
Files
Supplementary Appendix 1
Supplementary Figure A4-1
Supplementary Figure A6-1
Supplementary Figure A6-2
Supplementary Figure A2-1
Supplementary Table 1
Supplementary Table 2
Supplementary Table 3a
Supplementary Table 3b
Files
Supplementary Information
URLs
Medical News Today
URLs
Blood Highlight

Files
Manuscript
Figures
References
Raw data (mean scaled, see supplement)
Raw data (unscaled)
Sample annotation
2118 genes (Top 5% by F statistic)
4246 genes (Top 10% by F statistic)
ASH meeting presentation (slides)
ASH meeting presentation (handouts)
UNIGENE and GenBank annotation of Affymetrix
UNIGENE and GenBank annotation of Lymphochip
Lymphochip 2 Affymetrix mapping
Consensus Clusters' Markers
URLs
PNAS Supplemental Information

Files
PGC-1-alpha timecourse (scaled expression data)
Mouse promoters
Mouse:human masked promoters
Gene list for Figure 1 correlogram
Files
Technical Report
Leukemia data
Leukemia class template
Novartis multi-tissue data
Novartis multi-tissue class template
St. Jude Leukemia data
St. Jude Leukemia class template
Lung cancer data
Lung cancer class template
CNS tumors data
CNS tumors class template
Normal tissues data
Normal tissues class template
Uniform1
Gaussian1
Gaussian3
Gaussian3 class template
Gaussian4
Gaussian4 class template
Gaussian5.delta2
Gaussian5.delta3
Gaussian5 class template
Simulated6
Simulated6 class template
URLs
Same datasets as this paper

Files
Paper (Word document)
URLs
Multi-tumor Cancer Map Paper
Lung Paper
Breast Paper
Prostate Paper
Medulloblastoma Paper
Lymphoma Paper

Files
Manuscript
Supplement
Supplemental Information
Dataset A - Global Cancer Map Tumor vs. Met.
Dataset B - Lung Outcome
Dataset C - Rosetta Breast Outcome
Dataset D - Prostate Outcome
Dataset E - Medulloblastoma Outcome
Dataset F - LBC Lymphoma Outcome
Table of Contents

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