Norbert Perrimon

Norbert Perrimon is a professor in the department of genetics at Harvard Medical School, an investigator at the Howard Hughes Medical Institute and an associate member at the Broad Institute. His laboratory is using high-throughput, genome-wide RNA interference (RNAi) screens to assign phenotypic signatures, or “phenoprints,” to every gene in the fruit fly Drosophila melanogaster. These screens are based on a diverse set of cell-based assays, which rely on transcriptional analyses, protein modification, and high-content imaging to provide a wealth of phenotypic information. With these phenoprints, global correlations can be drawn to other large-scale datasets, such as transcriptional profiling and interactome data, in order to derive the network graphs critical for data mining. In addition, his group is taking a quantitative approach to elucidate the organization of signaling networks, using a combination of RNAi and gene expression profiling tools.

Learn more about research in the Perrimon laboratory here.